Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion

Formulation and Evaluation of Rofecoxib Liquisolid Tablets

The aim of our study was to improve the availability of Rofecoxib a practically insoluble non-steroidal anti-inflammatory drug, as a model drug by using liquisolid technique. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 25-mg Rofecoxib, which containing different...

Optimization and Formulation Design with In-Vitro Evaluation of Fast Disintegrating Tablets Containing Candesartan Solid Dispersions

The aim of this study was to assess the effects of processing parameters on the release of solid dispersion formulation from a fast dissolving tablet dosage form. Graphical and mathematical analysis such as the response surface methodology (RSM) and multiple response optimizations utilizing the polynomial equation were used to search for the optimal formulation and to quantify the effect of eac...

formulation and evaluation of domperidone fast disintegrating tablets and its taste masking using solid dispersion technology

Development and in vitro evaluation of ibuprofen mouth dissolving tablets using solid dispersion technique.

The aim of present study was to prepare and evaluate mouth dissolving tablets of ibuprofen (IBU). Ternary solid dispersion (SD) of IBU was prepared using PEG 4000 as carrier and Tween 80 as surfactant. The SD formulations were prepared by solvent evaporation and melt solvent method by varying ratio of PEG 4000. Different weight ratio of carrier, drug and surfactant 5 : 5 : 1, 10 : 5 : 1, 25 : 5...

Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions

Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...